Regardless of the notable selectivity of the various indirubin analogues, they all share a common interaction pattern with their target enzyme active site (for example, see PDB structures 1E9H, 2BHE, 1UV5, and 1UNH).
Regardless of the drawbacks of selectivity, one of the major benefits of using a substrate as a reporter is that a single active protease can process many substrates, thus leading to signal amplification over time.
One feature of our results that underscores the trade-off inherent in the choice of harvest regimes is that, regardless of the harvest's size-selectivity, less intense harvesting caused minimal evolutionary change (Fig. 4), but also resulted in low yields (Fig. 6).
By using tandem mutations, we were able to determine sequence selectivity regardless of the context of the amino acid.
As predicted, modeled migration speeds were highest with high drift tolerances, but not with FD behavior: both PC1 and PC2 populations exhibited higher migration speeds than FD populations, regardless of wind selectivity.
Regardless of the specific reason for the high selectivity of GSK199, our studies highlight the potential of exploiting the structural transitions that occur upon calcium binding to identify allosteric PAD inhibitors.
Using NiO/SBA-15 obtained by direct synthesis method, the CO selectivity was 100%%, regardless of the temperature (Fig. 4b).
High temperatures facilitated CO2 conversion to CO with CO selectivity close to 100%%, regardless of the synthesis method of the used catalyst.
The introduction of a hydroxy group to the derivatives increased the affinity and selectivity to the κ receptor regardless of the configuration at the 3-position.
Next, we asked whether caudate neurons represented category-related information regardless of the properties of the visual stimuli or their stimulus selectivity.
