Sentence examples for regardless of checkpoint from inspiring English sources

In these circumstances, cells with mutations allowing proliferation in the absence of functional telomeres and regardless of checkpoint activation would possess a huge selective advantage, which ultimately leads to cancer.

Results so far are consistent with the hypothesis that Aurora B is implicated in checkpoint signalling regardless of its proven function in error correction.

A recent study by Pires and colleagues [ 23] showed that cells that are exposed acutely to hypoxia are able to restart replication regardless of the presence of active checkpoint response and reoxygenation-induced DNA damage.

The binding of cyclins A2 and B1 to the APC/C was specific for mitosis, and occurred regardless of the strength of the spindle checkpoint (Fig. 3A; compare nocodazole- with taxol-arrested cells) (Collin et al., 2013).

After chemotherapy treatment in NSCLC-SCs, Chk2 phosphorylation and p53 activation in p53 proficient cells occurred days after Chk1 activation, suggesting that Chk1 acts as a major DNA damage checkpoint in NSCLC-SCs, regardless of the p53 status.

Regardless S checkpoint cell cycle arrest is a hallmark of ATM activation.

Together, these data reveal that proper dosage of CYB-3 is important for precision of timely execution of anaphase onset regardless of the presence of the MDF-1 checkpoint component.

His version of checkpoint guns are toys.

Proper functioning of the mitotic checkpoint requires the recruitment of checkpoint proteins to the kinetochore.

We propose that PP1Dis2-mediated dephosphorylation of checkpoint components forms a novel spindle checkpoint silencing mechanism.

Regardless of the mechanism, cohesin's role in S-phase checkpoint activation highlights a two-way crosstalk between cohesin and DNA replication.