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Viewing a complex structure be it an arch (or, for that matter, the Great Pyramids or Stonehenge), an organ, or a biochemical pathway only as it appears in the present, with no consideration of the scaffolding that may have been involved in its construction, can lead to undue pessimism regarding the plausibility of its assembly by comparatively unremarkable processes.
Consequently, these studies add further to the questions regarding the plausibility of the proposed modes of action.
The set of hypotheses proposed a priori can be chosen using previous knowledge and theory regarding the plausibility of various hypotheses.
We believe that the new in vitro data presented above and physiological data published recently (Cho et al., 2014) should dispel the concerns raised by Trimbuch et al. regarding the plausibility of the insertion/zig-zag model.
Our result prompts contemplation, at least, of the possibility of fewer origins, conceivably even a single origin in the common ancestor of the proposed clade (though there is disagreement among the authors of this work regarding the plausibility of this hypothesis).
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But one may as well turn things around and regard the plausibility of such theories as a good reason not to accept (P.4) unrestrictedly, as argued e.g. by D. Smith (2009), Oderberg (2012), and Lowe (2013).
After identifying the crucial need for methodological self-consciousness in prevention research and policy, we explore the implications as they relate to (i) the values embedded in the choice of research designs and strategies, and (ii) contrasting intellectual starting points regarding the biological plausibility of preventing mental illness.
The posterior probabilities on models summarize the overall support for each model, taking account of both the association data and prior beliefs regarding the relative plausibility of the four models.
This study has a number of serious limitations with concern regarding the biological plausibility of the findings [ 8, 44].
Doubts remain regarding the prebiotic plausibility of some of the schemes that have been investigated to date for RNA monomer synthesis (Shapiro, 1984, 1988, 1995; McCollom, 2013).
In addition, the exposure metric raises issues regarding the biologic plausibility of benzene as the underlying causal agent for the observed effects.
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CEO of Professional Science Editing for Scientists @ prosciediting.com