Invasive procedures are employed but data regarding efficacy are lacking [168].
Non-steroidal anti-inflammatory drugs (NSAIDs) require further investigation given mixed results regarding efficacy.
Behavioral strategies are recommended for menopausal symptoms, but little evidence exists regarding efficacy.
As a consequence, conclusions regarding efficacy and safety from these studies may be erroneous.
For patients with dysplasia refractory to RFA, data are limited regarding efficacy of endoscopic therapy.
Studies comparing these routes of administration of an antihistamine regarding efficacy and pharmacokinetic profile are lacking.
Drugs that inhibit ligands that bind RAGE have been tried in humans, but each has limitations regarding efficacy or untoward side effects [21].
In addition to issues regarding efficacy and potential side effects of triptans, other factors may affect patients' ability or willingness to treat early.
Conversion studies may help to fill some gaps in knowledge regarding efficacy and tolerability as monotherapy before larger-scale de-novo studies are started.
However, so far the oral administration has not been clinically compared to the intravaginal application regarding efficacy, side effects and patient satisfaction in a scientific sound fashion.
Validated in vitro models allow extensive device testing prior to in vivo studies which limits the numbers of animals required to reach conclusions regarding efficacy and safety.
