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A pilot EQAS for t,t-MA in urine, adopted to assess the reliability of data regarding benzene exposure, has been organized and carried out between 1996 and 1997 in Italy.
Several studies have been reported regarding benzene alkylation using unmodified zeolites like HZSM-5, Beta, HY, mordenite, TNU-9, SSZ-33,ZSM-12, MCM-22 and ITQ-22 [6, 12, 13, 14, 15, 16] as well as HZSM-5 modified with phosphorous and boron [10].
Our findings suggest two novel hypotheses regarding benzene toxicity.
Table 1 shows summary statistics regarding benzene exposure, age, body mass index, and weight.
The working group did not comment on the strength of evidence regarding benzene and MDS, although recent studies seem to suggest that it should also be regarded as having at least "limited evidence" (Irons et al., 2010; Schnatter et al, 2012).
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Regarding markers for benzene-induced disease, several biomarkers of exposure to benzene exist, including urinary metabolites of benzene s-phenylmercapturic acid (sPMA), benzene-induced depression of peripheral blood parameters (e.g., neutrophils and MPV), and adducts to hemoglobin and albumin [ 24– 28].
Such studies would by extension most likely be noninformative regarding the association between benzene and lymphoid neoplasms.
This raises questions regarding the range of benzene exposures over which BO-Alb and 1,4-BQ-Alb can serve as useful biomarkers.
Regarding the impact of benzene exposure in the French EDEN cohort (Slama et al. 2009), an association between personal maternal exposure in nonsmoking women and both head size and weight at birth was found.
Given our previous epidemiologic finding, and in light of the fact that the ASPEN modeled estimates are only available for select years, we were interested in whether existing monitoring data could be used to provide additional information regarding exposure assessment of benzene.
For instance, borazine (B3N3H6) shows a great similarity with that of benzene (C6H6) [17, 18] 18] and hence, it is regarded as inorganic benzene.
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