The registry includes no detailed information regarding adherence, and misclassification of non-adherent patients as users is possible.
Hospitals are given regular feedback regarding adherence and results.
However, there have not been any reports regarding adherence to, discontinuation of, and usage patterns of migraine abortive medications in Asian countries.
Multiple large observational registries and quality-improvement initiatives now are capturing data regarding adherence to practice guidelines and contemporary patterns of care for ACS.
Beyond concerns regarding adherence, understanding the impact of these digitally delivered behavioral interventions for headache is difficult because of the numerous confounding variables in many of the individual studies.
This gap in the care continuum is often exaggerated in vulnerable populations such as people who inject drugs and justice involved individuals who are more likely to experience social stigma, unstable housing, institutionalization, provider concerns regarding adherence, and other clinical and individual-level barriers (Harris and Rhodes 2013; Zeremski et al. 2013).
Regarding adherence to the severe sepsis bundles [13], only one PICU reported compliance to all the components of the first severe sepsis bundle (sepsis resuscitation bundle) and three PICUs reported compliance to all elements of the second severe sepsis bundle (sepsis management bundle).
The possibility that drug resistance evolved rapidly in drug susceptible cases receiving optimal treatment appears less likely based on clinical history and collateral information regarding adherence obtained from tuberculosis clinics and relatives.
Indeed, different modeling approaches using varied assumptions regarding adherence, percent coverage of ART-eligible individuals, survival, duration of infectiousness, and risk compensation arrive at different conclusions regarding the net effect of ART on preventing HIV transmission at the population level [17] [22].
Another limitation is the general lack of information regarding adherence to the drug therapy.
Questions covered five domains commonly cited regarding adherence to long-term therapies [ 11].
