Exact(2)
Thus, the gradual loss of IL-24 expression as melanocytes transform into aggressive melanoma cells and the regained expression of IL-24 in terminally differentiated melanoma cells may well be explained by differentiation-associated alterations in the activity of p38 MAPK, its downstream kinases and RNA-binding proteins.
Contrast to locus 1* segregants, locus 2* segregants from Lo2 271 hybrids have completely lost methylation and regained expression (Fig. S1 ).
Similar(58)
As shown in our example, the parasites may regain expression of surface molecules and binding to endothelial receptors within a short period of in vitro culture.
NOTCH1 expression is normally decreased in mature melanocytes, whereas melanomas regain expression and activity of NOTCH1 (Balint et al., 2005; Pinnix et al., 2009).
Lgr5+ amacrine cells could directly transdifferentiate into other retinal cells by turning off the Lgr5 gene and regaining expression of genes essential for new regenerated cells.
On the other hand, the breast tumour cell line MDA-MB-436 had a dense area of methylated DNA and did not regain expression of the CXCL12 gene when cultured with the demethylating agent 5-aza-CdR.
However, a study using a cell line that did not regain expression of E-cadherin showed that miR-200c was still inhibiting invasion and migration, suggesting that other pathways are involved which work independently of E-cadherin [ 44].
TrkB was shown to act as a mediator of anoikis resistance in both BT549 and Hec50 cells, and restoration of miR-200c caused decreased expression of TrkB protein concomitant with increased death of cells cultured on nonadhesive substrata; resistance to anoikis in the miR-200c-expressing cells was specifically regained by expression of a TrkB construct that could not be targeted by miR-200c.
Upon differentiation of the hiPSC into embryoid bodies, a large fraction of these hiPSCs regained EGFP expression and some of those cells became single positive for EGFP.
Among these 126 genes except 6 genes, rest of them regained their expression levels similar to WT. Therefore these represent "bona fide" Mta1 target genes (Table 3 and Table S5).
Although, lymph node cells that were depleted for CD4+CCR6+ cells regained CCR6 expression (Fig. S2A) nearly no IL-17 production was detected in those cells after in vitro re-stimulation for 3 days (Fig. S2B).
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