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The advantage of such a combinatory treatment is that before the next round of DNA-damaging therapy it will allow cancer cells to re-enter the cycle and regain sensitivity to cycle-active drugs, a regimen leading to improved therapeutic outcome.
Her new clitoris needs to be stimulated to regain sensitivity, which is where he comes in.
In order to create multiple gene deletions within the same parasite, it is critical that after the action of FLPe mutant parasites must regain sensitivity to the drugs used during selection.
We then investigated whether cells regain sensitivity to this treatment when they are grown as SDAC and increase receptors expression.
Also, it has been reported that melanoma cells are frequently resistant at the time of surgical excision, but regain sensitivity in cell culture (Nguyen et al, 2001).
In addition, adult F344 rats were tested for evidence of an endogenous rhythm of photoperiodic responses, by assessing whether mature rats that had become insensitive to short winter photoperiods would regain sensitivity in constant short photoperiod.
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Relapsed tumors resisted a second in vivo T cell treatment, but regained sensitivity to T cell treatment upon retransplantation in mice.
The present protocol was designed to study the polymorphisms in pfcrt and pfmdr-1 gene to determine any sign of regaining sensitivity to chloroquine among P. falciparum after five years of artemisinin combination therapy (ACT) implementation.
Regular monitoring is essential not only to determine the efficacy and development of resistance by the parasite but also to detect early sign of regaining sensitivity to any anti-malarial agent that has been withdrawn for a long period.
As expected, DNMT3A-depleted K562DR cells regained sensitivity to dasatinib (Fig. 2g).
Moreover, 2 out of 11 RITA UKF-NB-3 sub-lines regained sensitivity to RITA after cultivation for 10 passages in the absence of RITA, whereas all nutlin-3-resistant sub-lines remained nutlin-3 resistant.
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