Clients who refused consent for a rapid diagnostic test received presumptive treatment (current practice), and reasons for the refusal of consent were documented.
To evaluate whether race or ethnicity was independently associated with parental refusal of consent for their child's participation in a multisite pediatric critical care clinical trial.
Other important inclusion criteria included: Body Mass Index (BMI) of ≥ 17.0 kg/m2 at screening, and ability to provide informed consent, including refusal or consent for optional pharmacogenomic research.
Reasons for exclusion included supraclavicular nodal disease only (n=29), misclassification of recurrent disease (n=15), and patient refusal of consent for research use of clinical information (n=6).
The exclusion criteria were: multiple pregnancies, previous caesarean delivery, haemodynamic instability, severe anaemia (haemoglobin concentration <8 g/dL), chorioamnionitis, and refusal of consent for inclusion.
A total of 12 participants were not invited due to withdrawal (n = 2), refusal of consent for contact (n = 5), unsuitable for contact (n = 3), or death (n = 2).
Most convictions lead to a refusal of consent for donation: ' organ donation is a reason for premature death'; ' life is needlessly prolonged to obtain organs' or ' the potential organ donor has suffered enough'.
Thus, they are suitable for conservative treatment, especially when the patients have contraindications to operative intervention either because of medical reasons or because of refusal to consent for the procedure.
Fifty one children were excluded from undergoing this test either due to parental refusal to consent for the specific test and/or because they met one or more of the exclusion criteria.
Although nurses' refusal to defer consent for blood samples did not greatly impact on CATCH findings, 49 such refusal may have implications for other critical care trials, either burdening families if they are approached for prospective consent at an unsuitable time, invalidating trial results, introducing bias or resulting in missing data.
