Sentence examples for refractory toward from inspiring English sources

Primary human hepatocytes and primary human endometrial epithelial cells are also representative of epithelial cells that are responsive to EGF but relatively refractory toward in vitro proliferation.

The difficulties can be attributed to one of more of the following reasons: (1) the strain is difficult to culture (long doubling times) or domesticate; (2) the strain is genetically intractable and refractory toward common molecular biology tools; and (3) the polyketide biosynthetic pathways are weakly expressed or silent under laboratory culturing conditions, resulting in low polyketide titers.

While Th17 cells seem to easily convert toward a Th1 phenotype, Th1 cells are considered stable and mostly refractory to conversion toward Th17 cells or other Th subsets, suggesting that plasticity between Th1 and Th17 cells is rather asymmetric.

Importantly, this transdifferentiation appeared to be very stable since Th17-derived Treg cells were refractory to return conversion toward Th17 phenotype in presence of Th17 polarizing cytokines [ 86].

Consequently, that could jeopardize the baseline comparability of groups since it could be interpreted as certain channeling effect toward including more refractory patients in the generic cohorts.

Here, we found that large areas of the epicardium (particularly at the apex, the base, and toward the RV) were still refractory in the simplified model, whereas they were almost fully recovered in the complex model.

Of particular interest is the finding that the triplatinum species manifests potent antiproliferative properties toward Triple Negative Breast Cancer Cells, often refractory to most anticancer drugs.

Peripheral T cells express a memory/activated phenotype, differentiate toward T-helper-1 cells, and are refractory to peripheral clonal deletion.

For the dust in the dense molecular clouds along the lines of sight toward the GC, we assume that silicate dust and organic refractory dust are equally coated with an ice layer and then form a porous aggregate (see Li and Lunine, 2003b).

Graduate of John Hopkins, and possessed art of teaching refractory children.

The method is what one might call refractory.