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Interestingly, earlier studies had described a refractory state of cells to repeat interferon induction7.
One consistent characterization of these cancers, however, is their eventual progression to a hormonal refractory state.
Every resting cell of the automaton lattice takes excited state if there is exactly two excited neighbors, transitions from excited state to refractory state, and from refractory state to resting state are unconditional.
But if the losing state should oppose execution, refractory state officials, as individuals, would be liable to civil suits or criminal prosecutions in the federal courts.
Another potential cause is fatigue: perhaps some temporary refractory state is produced by repeated elicitation of the same response, making it impossible to perform that response again.
The development of effective novel therapeutic strategies requires an understanding of the mechanisms for the development of such a refractory state.
Similar(9)
The effects of clozapine on symptom reduction, neurocognitive function, and clinical management in treatment-refractory state hospital schizophrenic inpatients.
Epigenetic alterations, including methylation of key tumor suppressor genes, may play a role in the progression of prostate cancer to a castration-refractory state.
Recognition of this pseudo-refractory state can minimize the risks of prolonged TPE and the risks of adjunct interventions.
Once the disease progresses to the hormone-refractory state, there is no effective treatment currently available [38].
Although effective, taxane-based chemotherapy for HRPC can delay the fatal outcome by only a few weeks or months, emphasizing the urgent need for new concepts to tackle the hormone-refractory state.
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CEO of Professional Science Editing for Scientists @ prosciediting.com