Sentence examples for refractory over time from inspiring English sources
Sir, The majority of patients with hormone sensitive prostate cancer become hormone refractory over time.
"People change over time.
To verify that NSCLC TICs are refractory to cisplatin also in vivo, we injected severe-combined immunodeficiency (SCID) mice with H125 bulk cells and TICs, respectively, and assessed tumor growth (median tumor size) over time.
Treatment of prostate cancer patients with antiandrogens is initially successful, though the therapy often becomes refractory over the time.
While a refractory headache can improve or worsen over time also in relation to events independent of the headache, an intractable headache carries in itself the implication that the condition may never be improved.
Thus, studies evaluating the effects of catheter ablation in highly symptomatic, drug refractory patients consistently show an improvement over time that seems to be correlated to the restoration and maintenance of sinus rhythm and is also associated with objective measures, such as improvement in left ventricular ejection fraction and a decrease in left atrial dimensions.
However, it has toxic drawbacks and has limited-duration utility because, over time, human tumours become refractory to Tam.
Calcineurin and tumor necrosis factor-α antagonists may work in refractory cases, but the effects wear off over time and adverse events can be limiting (2, 3, 4, 5); see also FDA block warning on tumor necrosis factor blockers).
Some tumors, however, are refractory to these targeted therapies or develop resistance over time.
For children with many types of cancer including refractory leukemias, their capacity to demonstrate resilience wears thin over time.
