Sentence examples for refractory cells from inspiring English sources

Colon CSCs have been demonstrated to be highly resistant to standard-of-care chemotherapy7,8,11, and combination strategies leading to the suppression of these therapy refractory cells may ultimately translate into improved treatment efficacy and patient outcome.

This analysis detected 487 transcripts differentially regulated in the hormone-therapy refractory cells versus the parental PC346C.

Once cells reached confluence, the same procedure was repeated to collect the small refractory cells and expand them in new collagen 1-coated dishes.

This avoided the possibility that measured inhibition of Ca2+ release due to BA was in part due to refractory cells made so by prior treatment with agonist.

Expression array analysis was performed to explore whether the AR pathway is still active in the hormone-therapy refractory cells under androgen-deprived conditions and identify putative alternative growth/survival pathways.

Interfering with one member of this network, like IL-6 in our study, seemed to induce counteracting signals in refractory cells, in attempt to maintain their proliferation and anti-apoptotic signaling pathways at a certain level of activation.

In addition, it is difficult to obtain a single cell suspension of some adherent cell lines, including PC12 cells, due to refractory cell-cell adhesion.

Absence of several components in the β1-integrin signaling pathway leads to cell spreading defects and refractory cell motility responses.

The hormone refractory cell line DU 145 is highly resistant to Fas mediated apoptosis.

Nevertheless, further understanding the biological feature of the refractory cell population is important for the treatment of chronic HBV infection.

The in vivo anti-tumour effect of vandetanib against an in vitro-sensitive cell line (TKKK-Luc derived from TKKK) and an in vitro refractory cell line (OZ-Luc derived from OZ) was then evaluated using subcutaneous xenografts.