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Improvements in pMDI design and reformulation with propellants such as hydrofluoroalkanes may offer significant advantages over CFC-pMDIs and prolong the widespread use of pressurised drug delivery systems for many years to come.
Our framework provides the terminology to specify the conditions under which a particular reformulation technique is applicable, the cost associated with performing the reformulation, and the effects of the reformulation with respect to the problem encoding.
Hence, QS-21 is associated with injection pain in simple buffer formulations, but it is possible to improve the acceptability of QS-21-containing formulations through reformulation with certain excipients.
Despite these findings, the clinical research with these antigens continued following their reformulation with other adjuvants and/or combination with other antigens.
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We furthermore investigate theoretical properties of the different reformulations with regard to their numerical solution.
This study examines the facets and patterns of multiple Web query reformulations with a focus on reformulation sequences.
We worry that cannabis purification and reformulation combined with the commercialization of the cannabis industry in partnership with a new generation of vaporizers ("safe delivery devices") might lead to greater cannabis harms.
Similarly, on the snacks side, starting in 2005, we started a massive reformulation effort with Walkers and then Quavers and Monster Munch and all of those products, just to be ahead of the curve in the industry.
Recently, [27] considered an optimization reformulation approach with the regularized gap function.
In this reformulation, stops with single coverage, those only served by one line, are introduced in the hybrid model to improve spatial accessibility to avoid an increase in agency investment.
It also reformulates Pollack's (1990) definition of individual plans to handle cases in which a single agent has only partial knowledge; this reformulation meshes with the definition of SharedPlans.
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CEO of Professional Science Editing for Scientists @ prosciediting.com