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Although we did not specifically assess for GERD in this study, the possibility exists that the inverse association between H. pylori and asthma reflects protection from GERD.
This estimate was robust and maintained (≥90%) across most sensitivity analyses and primarily reflects protection conferred to children and young adults.
The exception was among young children where the reported incidence has remained stable and likely reflects protection resulting from pertussis vaccinations administered as recommended [ 9].
Such limited proteolysis of wildtype BiP generated a protected fragment corresponding in mass to the compact NBD (∼44 kDa) as well as an N-terminal 60 kDa fragment that accumulated only in presence of ATP (species 2 in Figure 5 figure supplement 1 and Figure 5 figure supplement 2) and thus likely reflects protection of the linker due to its engagement in interdomain contacts.
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Thereby OZ reflected protection of the cerebral architecture against STZ induced damage.
The OPN KO phenotypes we report reflect protection from insulin resistance that is associated with changes in adipocyte biology and adipose tissue inflammatory status.
Chronic AT, by contrast, markedly decreased the [Ca2+]i transient amplitude, perhaps reflecting protection from [Ca2+]i overload.
Moreover, interventions that diminish or delay loss of Thy-1 promoter activation after optic nerve crush may reflect protection of RGC health.
Brain lysine and alanine were both reduced in cMSUD pups with norleucine treatment (Fig. 9D), which may reflect protection of energy metabolism in the brain similar to changes found in iMSUD mice (Fig. 8).
Furthermore, improvements in endothelium-dependent flow-mediated vasodilatation have been shown following pitavastatin treatment in people who smoke, an effect likely to reflect protection of endothelial cells against oxidative stress [49].
In contrast, a high proportion of older adults receive seasonal influenza vaccine (9 ), and influenza type-specific rates of hospitalization in older age groups might reflect protection conferred by vaccination with the current season's vaccine and possibly cross-protection from previous influenza infection or immunization (10, 11 ).
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