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For example, gene expression profiling has been used to classify hepatotoxins based on mechanism of action and to differentiate early, presumably adaptive, responses from later responses that are reflective of toxicity (Hamadeh et al. 2002a, 2002b; Waring et al. 2001, 2003).
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Based on the similarity of immunotoxic effects (i.e., thymus atrophy) induced by DES, DEX, CPS, and TCDD, we hypothesized that they would induce an overlapping transcriptional profile in the thymus reflective of general toxicity in this organ.
A shared miRNA subset was detected across the assayed models of cardiac toxicity, reflective of consistencies in the cardiomyocyte response to injury.
Left ventricular size may merely be reflective of the accumulated cardiovascular toxicity of end-stage renal disease and regression of LVM may indicate an attenuation of these effects.
The decrease in coxib use at 36 months is likely reflective of both changes in medication availability and increasing awareness of toxicity during this period [ 24, 26, 38].
In the US, the cost of toxicity was assumed based on hospitalization costs associated with ICD-9-CM codes reflective of the toxicity.
We hypothesised that increased acute toxicity, measured using subdomains reflective of epithelial cell damage, will be associated with reduced late biochemical failure, as a surrogate for tumor radiosensitivity.
The worry of toxicity is hugely overblown.
They speak of "toxicity" and set out for Yukon.
pathway of toxicity.
It's a form of toxicity.
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