The screening cut points were chosen specifically for the Pre-Empt trial and reflected threshold levels for each of the health behaviours which could trigger intervention in UK general practice.
The predefined cut-offs for CD4 cell counts and the viral load in a risk-scoring system is useful because they reflect thresholds currently used to decide the initiation of HAART (e.g., CD4≤200 or 350 cells/mm350
These states broadly correspond with the stages of disease described in paediatrics, and also reflect thresholds between different therapy regimes [ 14].
The parameter ACTIVATION THRESHOLD reflects a threshold dividing the two distinct modes of cellular behavior, in stay and in move.
Each item was scored on a 5-point scale (0 4), with lower scores, in the 0 2 range, reflecting putative threshold criteria for insomnia disorder (shaded area: see appendix).
PC2 represented the downward slope of the audiogram reflecting worse thresholds at higher frequencies, and PC3 gave a measure of audiogram concavity (how much the audiogram deviates from a straight line).
Alternatively, the regional phenotypes may reflect different threshold requirements for striped Lfng in different body regions.
This may reflect a threshold effect in which the magnitude of changes between R6/2 and WT mice – up to 2-fold difference for some neurotransmitters – would surpass the specific effect of CAG repeats.
However, it remains unclear whether this response reflected a threshold for intracellular signalling or more complex events such as the action of co-stimulatory molecules on the antigen presenting cells.
This negative correlation reflects the threshold reduction induced by adaptation at high contrast in migraine, as illustrated in Figure 3.
