To address this, we next investigated the expression of markers potentially reflecting T cell activation including GITR, CD62L and CD69.
Although the function of glucocorticoid-induced tumor necrosis factor receptor related protein (GITR) remains to be fully elucidated, it is generally accepted that GITR expression is increased upon TCR engagement, reflecting T cell activation [42].
IL-7R density was associated with physiological alterations in immune cell subsets reflecting T-cell maturation/differentiation.
Genome-wide expression arrays showed evolution of immune responses reflecting T-cell activation and recruitment with uniquely Th1-polarized responses and cytotoxic T cells (CTLs).
We show that in ER negative basal and HER2+ breast cancer, gene expression modules reflecting T-cell helper-1 (Th1) and T-cell helper-2 (Th2) mediated immune responses play antagonistic roles as major risk factors for distant metastasis.
Therefore, we used selected gene expression profiles reflecting T-cell subsets 7, 8 together with a panel of T-cell activation and proliferation markers, to probe transcriptional profiles in TST samples (Fig. 2).
Barros, M. H., Segges, P., Vera-Lozada, G., Hassan, R. & Niedobitek, G. Macrophage polarization reflects T cell composition of tumor microenvironment in pediatric classical Hodgkin lymphoma and has impact on survival.
For an isotropic sky model, global irradiance on the tilted surface is defined in [17] by the equation below with g represents global, d represents direct, df represents diffuse, r represents reflected, t represents tilted, gr represents ground.
DTH responses reflects T cell function in vivo (e.g. IL-2 production) and is an independent predictor of disease outcome [20], [50], [51], [52].
Although most HCV-2c sequences deposited in Genbank were obtained from samples from Europe, mainly France and Italy [8], [15], this may not reflect t a possible European origin of the sequences, but rather that these countries have carried out more detailed epidemiological studies.
Hyperferritinemia generally reflects the activation of macrophages in HLH, while elevated levels of sIL-2R reflect T cell activation [ 10– 10].
