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Patients with panic disorder and depression exhibit an attenuation of 5-HT1A receptor-mediated neuresponseine reflectingreflecting dysfunction of pre and postsynaptic 5-HT1A receptors [ 35].
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These impairments may reflect dysfunction of the anterior cingulate network within the frontostriatal pathway.
Considered by some as intentional deception, such 'denial' might instead reflect dysfunction of brain networks subserving insight and self-awareness.
In humans, stereotypies are associated with several psychiatric disorders and are thought to reflect dysfunction of inhibition of motor programs mediated by the corticostriatal circuitry, resulting in recurrent perseveration (=inappropriate repetition of behavioural responses).
Slow proliferation of NCS fibroblasts might also reflect dysfunction of the mTORC1 signalling pathway.
Reduced binding in the striatum reflects dysfunction or loss of nerve terminals in the substantia nigra.
Psychogenic dystonia may reflect dysfunction of these fronto-subcortical circuits, rather than a disorder of motor cortical plasticity and metabolism.
In the absence of coronary stenoses, a reduced coronary flow reserve (CFR) reflects dysfunction of the coronary microcirculation.
It is thus likely that our regional abnormalities do reflect dysfunction related to AD and FTD pathology.
Changes may reflect dysfunction of the phylogenetically old subconscious retino-colliculo-thalamo-amygdala and retino-geniculo-extrastriate pathways.
Slowed motor activity and difficulties in self-initiating movements, common to melancholic depression, negative symptoms in schizophrenia, and Parkinson's disease, may reflect dysfunction within frontostriatal circuits [ 54].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com