We thus hypothesized that impaired extinction in the IMMED rats might be reflected by a failure of IL neurons to increment their firing to an extinguished CS.
Taken together, cellular resistance to HSP90 inhibitors is reflected by the failure of such inhibitors to destabilize HSP90 client proteins.
It is widely documented that poor outcome is reflected by microsurgical failure to adequately address nerve regeneration at the cellular level.
Analysis of these samples revealed a loss of CD3+CD8+TM+ T cells that was specifically noticeable in the samples spiked with low frequencies of NY-ESO-1-specific T cells and reflected by a failure to detect low-frequency T cells and a loss of the linearity of detection at the lower frequency range.
It should be noted that the patients included in the study had long-standing destructive disease (median disease duration 10 years) and had previously failed to respond to aggressive therapy, as reflected by a failure to respond to a median of four disease-modifying antirheumatic drugs.
Although P53 is not commonly mutated in metastatic melanoma and can transcriptionally activate certain target genes in response to stress [ 5, 17, 18], its function is abnormal as reflected by a failure to induce cell cycle arrest and apoptosis [ 1, 18].
The use of ICSI was associated with lower odds of implantation (OR = 0.59; 95% CI: 0.31, 1.13), likely because couples using ICSI have poorer fertility, as reflected by prior failures of IVF without ICSI.
The GTP-locked Rab7-Q67L han an increased activity that is quantitatively reflected in its localization to late endosomal compartments, whereas the GDP-locked Rab7-T22N is considered inactive, as reflected by a complete failure to be recruited to endosomal compartments.
The variables age, sex, sepsis, neurosurgical patient, steroids, adrenaline and/or noradrenaline infusion rate, acute renal failure, liver function assessed by the Model of Endstage Liver Disease score [ 1], organ dysfunctions reflected by the Sequential Organ Failure Assessment score [ 2], and severity of disease by the Simplified Acute Physiology Score II [ 3] were monitored.
All patients had long-standing active and refractory RA, reflected by a mean baseline failure of 3.9 DMARDs and a mean disease duration of 10 years at baseline.
