The lower rates of haematologic and overall grade 4 toxicity compared to those reported in INT0116 (54 and 32%, respectively) may reflect the chemotherapy regimen employed, particularly the use of continuous infusional 5-FU, which is known to produce less myelotoxicity compared to bolus 5-FU.
14 These side effects are common hyperoestrogenic symptoms and might reflect the fixed dose regimen in this trial, which was relatively high for women aged over 60.
A more variable prevalence of obesity was reported in adults with CAH, but this may reflect the higher dosing regimens used in the 1970 and 1980s.
Other studies have not observed this effect (20) which reflect the different immunosuppressive regimens deployed, or delays in transplantation and cold ischemia times which affect cell viability.
His advice reflected the new regimen under way at Manhattan Eye, Ear and Throat Hospital, where hundreds of workers and possibly thousands of patients and visitors began taking antibiotics after an employee there was exposed to inhalation anthrax and died, even though no evidence has turned up that the hospital was the source of the anthrax.
This reflects the drug regimen guidelines [ 35, 36] for the acute coronary syndrome, which recommend the use of clopidogrel, an antiplatelet drug, as follow-up treatment for up to 9 months only.
No strictly uniform dosing strategy for aerosolized colistin was applied, and differences in regimen reflect the differing approaches of the individual attending physicians.
Thus, when using questionnaires standardized in healthy populations, scores may be elevated in both type 1 and type 2 diabetic patients due to items that reflect the diabetes self-care regimen.
These include the creation of tunnel states to capture the rapidly diminishing utilisation and mortality through the first years on ART, and the provision of Markov states that reflect the strict two ARV-regimen approach to care contained in the WHO and South African national ART guidelines.
It was prespecified that data from elderly patients randomised to this enforced and atypical flexible dosing regimen were not included in the meta-analysis because this type of regimen does not reflect the intended use of IDeg in clinical practice.
