Purpose: To evaluate the efficacy and tolerability of levetiracetam as add-on therapy in patients with refractory partial-onset seizures in a protocol designed to reflect clinical practice.
Furthermore, although existing guidelines may accurately reflect clinical practice, most performed poorly when evaluated for quality.
We feel this may reflect clinical practice, where physicians in the UK are more likely to be trained and actively performing this procedure, reinforcing the external validity of the survey results [54].
A limitation of the whole-brain task was that each slice was presented for a fixed 1500-ms duration which does not reflect clinical practice in which clinicians can scroll freely through the image in any direction at their desired speed.
PP analysis might violate randomization and not reflect clinical practice very well.
For superiority trials, ITT analysis is the preferred analysis as it adheres to randomization [11] and might best reflect clinical practice.
Another issue is that the diagnostic criteria are "operational", meaning that a minimum appearance of symptoms are required to fulfill a diagnosis, which does not always reflect clinical practice [6].
To reflect clinical practice, the trial allowed presumptive and confirmed diagnoses as long as appropriate treatment for the OI/BI had been initiated (cryptococcal disease was required to be confirmed).
Definitions of multimorbidity should both inform and reflect clinical practice.
To reflect clinical practice, all doses of medications were rounded to the nearest full vial.
Using a simulation film set does not fully reflect clinical practice.
