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Efficacy endpoints should be selected to reflect clinical benefit.
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Optimization of clinical trial design should include the choice of clinical end points which provide mechanistic proof-of-concept and also reflect clinical benefits (e.g., surrogates to assess increased collateral flow reserve, such as myocardial perfusion imaging).
However, this theory does not always reflect clinical reality.
Which aspects of the pharmacogenomic testing strategy reflect clinical utility/benefit above current practice (eg, improved clinical validity, less invasive testing).
9 44 This might either reflect clinical uncertainty, despite the presence of guidelines, or the complex interaction between tumour characteristics, the information presented to patients, and their evaluations of the risks and benefits involved.
These data may reflect the clinical benefit that patients could receive when stepping-up treatment to combination therapy.
We chose β1 = 0 in order to reflect little clinical benefit (e.g. a sensitivity of 50%) and in contrast β2 = 2 (e.g. a specificity of 88%).
Until recently, doctors could shrug off data like Dr. Beam's as not reflecting clinical realities.
Overall, the pathology reflected clinical status.
Importantly, blood pressure was reduced similarly in both treatment groups, so that comparison of end points between treatment arms reflects the net clinical benefit of each drug over and above blood pressure lowering efficacy.
The pattern of cerebral dopamine (DA) abnormalities in Huntington disease (HD) is complex, as reflected by the variable clinical benefit of both DA antagonists and agonists in treating HD symptoms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com