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Endpoints need to reflect benefit to patients, and show that changes in tumour size either in absolute terms (response and progression) or relative to control (progression) are clinically relevant.
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In designing such criteria, individual components must be chosen and weighted such that a favourable score reflects benefit outweighing risk to a meaningful degree.
Whether this reflects benefit of withholding any nutrition, irrespective of the route, or more deleterious effects of more PN remains to be studied [ 64].
Relationships between Mayo scores and both PRO measurements were stable, in the right direction (reflecting benefit to the patient), and approximately linear.
Whether this reflects benefit of metformin, adverse effect of insulin, or difference between type 2 diabetic patients requiring the two agents cannot be deduced from the reported associations.
Hence, irisin reflects benefits of exercise and muscle activity.
Practice and coverage indicators provided the hard benchmarks to assess success or failure, as they directly reflected benefits to the population.
The figures are not seasonally adjusted, so some August gains reflect the benefit of the summer buying season.
"Their share prices will start to reflect the benefit as people become more confident in a U.S. rate cut early next year".
The estimates by IHS Global Insight reflect the benefit on the German manufacturer of government measures in China, Germany and Britain to prop up their automotive industries and stimulate consumer demand in the wake of the worldwide economic downturn.
Efficacy endpoints should be selected to reflect clinical benefit.
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