The clinical implication is that pathological levels of plasma sVEGFR1 may not necessarily indicate altered sVEGFR1 production or altered availability of free VEGF, because they may partially reflect altered receptor expression in tissues.
Thus, the observed lack of skin blanching in septic patients may reflect altered coupling between gluocorticoids and glucocorticoids receptors.
Thus, the worse outcome in patients with shock who had compromised skin microvascular reactivity after the thermal challenge may reflect altered NO pathways.
These significantly lower PPT thresholds in the trapezius muscle and suboccipital sites reflect altered pain perception in this regions and support the pathophysiological model of sensitization in migraine and chronic TTH [32].
The differences in the ability of Ynd1 mutants to mediate E4orf4-induced toxicity could possibly reflect altered subcellular localizations.
Literature values were used for this tissue in all cases, and changes in bone reflect altered plasma PK profiles.
Alterations in the expression of Homer1 in A53T-SNCA overexpressing mice from an early age in several brain areas may reflect altered activity and plasticity at excitatory synapses.
Here we validate that microRNAs are present in body fluids and moreover, demonstrate that microRNA levels in serum reflect altered physiological conditions, such as pregnancy.
The higher trait anxiety levels in the abnormal VTA/SN subgroup are consistent with research connecting the VTA/SN to expectancy processing [84], and connects with the idea that abnormal anxiety may reflect altered expectancy [86], [88].
The greater distance between these two clusters in LMNA mutant nuclei is consistent with a more relaxed and open conformation to the chromatin in this genomic region and may also reflect altered interactions with transcription factors and transcriptional machinery.
For mRNA must be translated into protein to have a biological effect whereas microRNAs are themselves the active moiety, often influencing the expression of multiple other genes, and thus likely reflect altered physiology more directly.
