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These data suggest that sciatica patients referred to spine surgery have decreased HRV when compared with healthy subjects, and this may reflect a predisposition to impaired autonomic cardiovascular regulation.
In addition to direct effects of certain substances on sexual decisions, 10 this may reflect a predisposition towards risky behaviours in some individuals 11 since alcohol and illicit drugs and smoking are strongly associated with adolescent sexual risk behaviour.
It is not known whether the changes in the cortical responses to hypoglycemia are part of the hypoglycemia-induced syndrome of unawareness and counterregulatory deficit, in which case they should be reversible, or whether they reflect a predisposition to respond to stress in this manner.
A possible explanation is that these acute toxicities were so severe that healing was not possible; alternatively this may reflect a predisposition to toxicity amongst certain patients, possibly related to either tumour location (e.g., close to critical structures) or genetic makeup.
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This genetic component is not inexorable, but reflects a predisposition that renders some people significantly more vulnerable to alcoholism than others.
Typical sites of involvement in Aspergillus vasculopathy include the basal ganglia, thalami and corpus callosum, reflecting a predisposition to involve the perforating arteries, as well as the subcortical regions.
A large body of evidence supports the association between stress, clinically significant depression, and activation of the immune and neuroendocrine systems (Woiciechowsky et al. 1999; Berk et al. 2011; Gibney and Drexhage 2013), although it still remains unclear if differential reactivity to stress reflects a predisposition or a marker of illness activity or both.
7 However, if clustering reflects a predisposition towards risky behaviours in some individuals, 11 then we might expect clustering to be less evident in periods when such behaviours are more prevalent.
The symptomatic associations we have seen may reflect a familial predisposition to other dimensions of psychopathology, such as externalizing disorders or anxiety states.
If this bacterial species alone is responsible for the typhlocolitis, it might reflect a particular predisposition to proinflammatory immune responses in IIJ mice.
While it is premature to speculate extensively in the absence of replicating data, these symptoms may reflect a familial predisposition to other dimensions of psychopathology, such as externalizing disorders or anxiety states.
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