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Several clustered motifs are located close to poly(A) sites, which may reflect a function for these clusters in polyadenylation, as discussed below.
Since the eggs under study resulted from sumo GLCs, the observed eggshell defect could reflect a function for SUMO upstream of EGFR in the production or secretion by the germ line of EGFR ligands.
Differences across genders may reflect a function of the reference system used, or a biological response to the higher energy needs of men vs. women.
The reduced viability of Tex19.1 −/− embryos could reflect a function for Tex19.1 in the placenta, or in pluripotent cells, where it is also expressed.
Such genes would reflect a function of all three proteins - presumably due to their complex formation or a tight regulation of each other - in regulation of the respective target genes.
Interestingly, because we see a similar effect with both HD and LD mutants, this does not appear to be related to catalytic activity but could reflect a function for the HIRAN domain or a structural role.
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Arousal reflects a function of the ascending reticular activating system (ARAS) [9], while awareness is more complicated and has been attributed to the functional integrity of the cerebral cortex and its subcortical connections [10, 11].
Whether it reflects a function of instinct or basic survival, we seem to neatly package and compartmentalize these crises and their meaning as "beyond our control or understanding".
I assume the authors think it reflects a function – recognizing the oddball tone and redirecting behavior generally.
A co-evolution of these bases with the editing site most likely reflects a function for these bases in editing-site processing or recognition.
It is possible that this SQRD-1 expression pattern reflects a function of SQRD-1 to prevent H2S from reaching the interior tissue.
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