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BAG1, encoding a Bcl-2 non-homologous associated molecule, has also been shown to present a decreasing gradient of expression from the base of the crypts to the apex of the villi, suggesting that the down-regulation of BAG1 might reflect a differentiation state of IEC [ 38].
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Our results suggest that the observed variability in hair cell voltage dynamics could have functional significance, reflecting a differentiation of hair cells into distinct groups specialized to sensory input of disparate frequency content.
It is generally accepted that mature adipocytes do not regularly undergo mitosis, and thus, an increase in adipocytes usually reflects a differentiation of preadipocytes [13] [14].
This effect does not appear to reflect a better differentiation between stimulation and no stimulation, but suggests an increased readiness to detect stimulation, even when there was none.
These cases may reflect a geographical differentiation of apomictic and sexual cytotypes between the Alps and the Tatry as also observed in Hieracium (Mráz et al., 2009).
The expression of these EMT-associated genes in tumor cells may therefore reflect a basal differentiation program and not necessarily indicate cells that have undergone EMT [ 15].
Our data suggest that these emotions are organized according to 2 main dimensions, which are only partly compatible with Arousal and Valence but more likely reflect a finer differentiation into 3 main classes (such as Vitality, Unease, and Sublimity).
Although this may be due to incomplete knockdown of FoxA, alternatively, it may reflect a block in differentiation of pharyngeal tissue, which requires FoxA activity.
We considered the possibility that the increased Sox2 levels in p27 null EBs could reflect a skewed neural differentiation, but the levels of Nestin mRNA were similar in WT and p27 null EBs.
Both, metaplasia and biphenotypic leukaemia/lymphoma represent examples of dysregulated cell differentiation that reflect a history of trans-differentiation and/or epigenetic reprogramming.
It is difficult to know whether the failure to identify lateral PFC regions showing both control modes reflects a functional differentiation between proactive and reactive control modes, a lack of statistical power, or the omission of factors that are critical for dynamic shifts in control within specific brain regions.
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