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Do high house prices reflect a deficient supply of new homes?
Patients with elevated NLR usually have relative lymphocytopenia, and this may reflect a deficient immune response to tumors mediated by CD4+ T-helper and cytotoxic CD8+ cell [ 34].
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Bach-Mizrachi et al. reported that higher TPH2 expression in depressed suicides may reflect a homeostatic response to deficient brain 5-HT levels [ 45].
Additionally, it has been reported that higher TPH2 expression in depressed suicides may reflect a homeostatic response to deficient 5-HT levels.
Schizophrenic patients also suffer from disturbances in information processing, reflected as a deficient sensorimotor gating, which may contribute to the cognitive deficits that characterise this disorder [ 76].
The increase in apoA synthesis in livers of CD36−/− deficient mice may reflect a PXR-mediated increase in apoA-I gene transcription.
We had also observed an increased FOXO3a protein level in MST1 deficient fast muscles, which might reflect a functional compensation by FOXO3a for MST1 deficiency.
Given that these signaling elements play an important role in central B-cell tolerance, however, it is not entirely clear to what extent the increased levels of autoreactive B cells after the peripheral checkpoint reflect a defect in peripheral selection per se in MyD88-deficient, IRAK4-deficient and UNC93B1-deficient patients or whether they are a consequence of defective central tolerance.
Additional in vitro studies suggested that this could be due to a direct contribution of the toxins to penetration of brain endothelium; however, we cannot exclude the possibility that the lack of clinical symptoms observed during infection with the toxin-deficient mutant may partially reflect a generalized reduction in virulence.
This may reflect a heightened response or defective negative regulation in Gαi2-deficient cells.
In particular, telomerase-deficient mice display hypersensitivity to ionizing radiation and delays in DSB repair that may reflect a defect in HR [37].
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