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Sabin also worked closely with the design and engineering firm Arup and their structural engineer Clayton Binkley on refining the structure.
We begin with some observations on the structure of von Neumann regular right self-injective rings which will help us in refining the structure of endomorphism rings of ({mathcal {X}} -automorphism invariant and ({X}} -automorphismomorphinvariantandant modules.
However, the changes in ribosome profiles and rRNA structures in multiple mutants suggest the intriguing possibility that they may each contribute to refining the structure and function of the translational apparatus.
Lawrence Chun performed all crystallographic experiments and participated in refining the structure, presenting results, and writing the paper.
Many of the gene structures from other species of nematodes have been based on the structure of their C. elegans ortholog, either directly by referring to the C. elegans gene while manually refining the structure of the gene or indirectly by training gene predictor programs on the C. elegans gene structures and then using these gene predictors to predict genes in other nematode species.
Model structure refinement with molecular dynamics: The resulting CYANA model was subjected to exhaustive MD simulations with the aim of further refining the structure, to evaluate its (short-term) stability and to confirm the presence of a stable minor-groove binding mode of Λ,Λ-B that satisfies, on a time average, the intermolecular NOEs.
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The SmKDAC8 biochemical results confirmed: (1) the benzodiazepine moiety as a valuable scaffold to further investigate when pursuing SmKDAC8 inhibition; (2) the predictive capability of the COMBINEr 2.0 model towards non-congeneric series of compounds, highlighting the most influencing ligand-protein interactions and refining the structure-activity relationships.
D.K. built and refined the structure.
H.-J.C. processed diffraction data, solved and refined the structure, and assisted with preparing the manuscript.
C.O. optimized purification, performed LCP crystallization, harvested crystals, collected and processed X-ray diffraction data, and solved and refined the structure.
They will work with the leaders of the units involved to refine the structure and operations of this expanded Office of the Dean for Undergraduate Education and Student Affairs.
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