The accurate identification of SCEs is also important for the functions of BAIT which assemble and refine reference genomes (see sections below).
BAliBASE was the first large scale benchmark specifically designed for MSA, providing high quality manually refined reference alignments based on 3D structural superpositions.
This ability to discern which template strands were inherited by dividing cells can be used for a number of important applications including the high-resolution mapping of SCEs, analysis of genomic rearrangements, and refining of reference assemblies.
Further refining the reference calls based on consistency with other inbred strains (sequenced as described in Whole-genome genotypic characterization of existing medaka inbred lines), we produced a revised reference assembly, which we submitted to the ENA as a Third-Party Annotation (accession nos. HF933207-HF933230; see Materials and Methods for more details).
This section provides detailed description of these categories, validated and refined through reference to other contexts.
The general results from the literature have then been validated and refined with reference to warehouse design companies.
Further work in this context will be to refine the reference model and its associated architecture work around other use cases such as data-staging or simple store for example.
To refine the reference range for the zinc protoporphyrin to heme ratio (ZnPP/H) of preterm infants, we assessed the impact of maternal risk factors on ZnPP/H and evaluated the impact of changes in iron supplementation on iron status.
The important thing, though, is that we would never have realized or have begun to understand this if we had not started from a hypothesis that all life did have a common origin which we could test and refine by reference to the structure of the living world around us.
We deemed it unacceptable to refine the reference atomic coordinates against the simulated low-resolution structure factor data as that would almost certainly bias the resulting refined structure towards the reference structure.
