The original 2003 protocol involved an impression and a rapid fabrication of an acrylic resin FDP within 2 h, although later refinements involve both a prefabricated adaptable FDP as well as all-on-six approaches in the maxilla (Pomares 2009).
It took around two years of hard work to develop our new system and there was a huge amount of design, testing and refinement involved.
Refinement involved iterative cycles of manual building and refinement calculations.
In addition, we examined whether the increased refinement involved the recruitment of adjacent cortical area.
The refinement involved iterations of manual model-building in Coot and Refmac.
The structural refinement involved 567 restraints, which included distance, dihedral angle, sugar pucker, and Watson−Crick hydrogen bonding restraints.
The structural refinement involved 527 distance restraints, including 296 intraresidue and 231 interresidue restraints, obtained from the intensities of NOE cross-peaks.
In many cases, this refinement involved choosing a GO term for the mapping that is further up the hierarchy and is less restrictive with respect to the taxonomic groups it can be used with.
Outside of the superplastic regime, grain size refinement involving recrystallisation and the formation of voids and cavities cause macroscopic softening; low ductility results.
