40 Greater awareness of a prodromal/pre-motor stage of the disease; efforts toward early and accurate diagnosis; and the continuous refinement of treatment paradigms, provide an opportunity for discussion on the use of potential disease-modifying agents to slow or halt the progression of motor and non-motor disability.
Such an understanding would allow patient selection, monitoring of therapeutic response and refinement of treatment protocols67.
Improvements in the clinical outcomes of rhabdomyosarcoma have been secondary to the intensification and refinement of treatment investigated by the Intergroup Rhabdomyosarcoma Study Group.
Identification of potential new mammalian radiation responsive genes/pathways promises refinement of treatment protocols and the possibility of tailored therapy.
Ongoing technological advances and refinement of treatment protocols may further improve feasibility.
For TFCBT, work along these lines has lead to a refinement of treatment programs, which has led to improved effect sizes (Öst, 2008).
There is currently no call for a change in this recommendation (Tattersall, 2002), although the availability of mature data from the ICON-3 trial offers an opportunity for review and refinement of treatment guidelines.
The transformation temperatures are much influenced by alloying addition, grain-refinement, thermomechanical treatment, etc.
Common to all surgical disciplines is a trend that as mortality decreases for a particular disease process, focus is adjusted, and refinements in treatment protocols are designed to minimize morbidity of the disease and its treatment.
It is well known that while the use of mechanical treatments is able to generate an effective field of compressive residual stresses and, if severe parameters are used, to cause grain refinement, thermochemical treatments are able to increase the surface hardness.
