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These tools could enable a shift from a costly case-by-case RA of MNs towards a targeted, flexible and efficient process, based on grouping and read-across strategies and compliant with the 3R (Replacement, Reduction, Refinement) principles.
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The big one, of course, is that perpetual refinement principle.
The refinement principle of systems states that any system S in ({mathfrak {U}}) can be deductively specified and analyzed with increasing details at different layers, (0 le k le n), from the top down.
The algorithm breaks each polyphase into non-overlapping Q-grams and bases its search on a successive refinement principle by employing beam pruning technique.
We hope that future testing and refinement of principles extracted from our review will define a path toward sustainable river basin design.
30/2833 held by T.H. with a strict implementation of the Replacement, Reduction, and Refinement (3Rs) principles.
While ensemble refinement in principle can be used to include dynamical effects, one limitation is that such calculations are more prone to being underrestrained than standard single-molecule refinement is.
At one time it was believed that errors of measurement could eventually be eliminated through the refinement of scientific principles and equipment.
However, the knowledge of the underlying probability distribution of faults, that would enable a systematic approach and refinement of these principles, is still quite limited.
While these pioneering studies have reported such interaction in very stark qualitative terms, advances in high-sensitivity imaging should allow refinement of these principles based on strict statistical tests of information theory.
To comply with 3R (reduction, replacement, refinement) animal experiment principles, a total of 9 rhesus macaques were used.
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