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The investment in such a refinement of the risk assessment, e.g., in the form of mathematical models or more complex experimental studies (aquatic mesocosms, and field studies) is usually worthwhile for the applicant company.
Many CT findings that may allow refinement of the risk stratification are still under evaluation.
If the PEC:PNEC is >1, further refinement of the risk assessment is generally appropriate.
Further refinement of the risk profiles for predicting PTB is needed by using a stronger design, such as a prospective longitudinal cohort.
Therefore, exposure characterization is useful for establishing the scope of concern regarding environmental release of a biofeedstock crop and, thus, can be used to guide problem formulation for refinement of the risk assessment.
This creates the need for more homogenous cohorts of patients within the administrative data, so that meaningful analysis can be performed more reliably, but also for a refinement of the risk adjustment methodologies that would make them more longitudinal.
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For a PPP that could already be authorised, all justifiable options for the management of the environmental risks should first be exploited before the authorities approve and accept highly complex refinements of the risk assessment whose only aim is to create more favourable conditions for application of the PPP (e.g., narrower margins to adjacent surface waters).
In addition, given the high rates of CHD and recurrent CHD events in adults with diabetes, refinement of these risk equations may help to identify high-risk populations that can benefit from public health approaches to risk reduction.
Numerous applications of the existing population maps are planned to exploit the increased spatial resolution, including the refinement of malaria risk and burden estimates [26], health system commodity estimation and medical facility accessibility modelling [18].
The refinement of geographic risk from our analysis may in part be the result of a reporting bias that produced larger than expected risk differences for certain areas.
However, it is generally acknowledged that these parameters are more useful to identify patients at low risk for complications, leaving room for refinements in the risk stratification of FN patients.
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