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From an animal-ethical point of view, a refinement of the procedure is highly desirable.
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The paper also discusses further refinements of the procedure by incorporating existing refinements of untyped resolution.
Transplantation of all or part of the pancreas is not completely successful, and further refinements of the procedures (first performed in 1966 by Richard Lillehei) are needed.
The experimental setting described below was designed according to the findings from several test runs leading to a progressive refinement of the laboratory procedure due to an increasing expertise.
Further refinement of the latter procedure is underway.
Furthermore, an improvement has been observed over the results of the clinical trial because of the refinement of the surgical procedure.
As a means to increase referral rates, further refinement of the MIND procedure could be considered, linking MIND outcomes to identified referral pathways as part of a collaborative care program (5).
Nonetheless, we conclude that there is sufficient evidence to support the continued use and refinement of this procedure as a treatment for corneal stem cell deficiency.
Information regarding study recruitment, acceptability of study processes and measures, and data quality would allow refinement of the evaluation procedures and effect sizes to be calculated and used for power calculations to establish the necessary numbers for a fully powered RCT.
Our study has an explorative character and should therefore be continued in new experiments, for further refinement of the instructions and procedure.
Unlike traditional refinement methods, the procedure of the RCR converges to a significant depth map faithful to the input no matter how many iterations are performed.
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