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These results provide mechanistic links of microbial metabolism to GHG fluxes that are needed for the refinement of model predictions.
Specifically, the knowledge gained provides more mechanistic detail about the metabolic potential of the soil microbiome and can help to define the metabolic routes for GHG production for refinement of model predictions.
We also show that the properties of Kolmogorov ecological systems can be exploited to provide a computationally efficient method for the refinement of model parameters which can be used to precondition parameter values used in standard optimisation techniques, such as genetic algorithms, to significantly improve convergence towards a target equilibrium state.
Refinement of model and topology heavily relies on more experimental data.
In addition, we have included parameters that allow for further quantitative refinement of model predictions: reaction weights (W) and maximum activity values (YMAX).
If an accurate and unbiased description of the data is required, further refinement of model structure and parameter values may be required.
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Refinement of modeling will lead to a unified, more robust estimation of background threshold.
Acquiring knowledge from a domain expert involves the construction, validation, and refinement of models.
CycSim facilitates the identification of inconsistencies, the design of new experiments and the iterative refinement of models using experimental data.
The protocol can also be applied for the refinement of models derived from medium-resolution NMR data.
Researchers are encouraged to follow guidance on key variables to report that would enable greater comparability and support replication and refinement of models in research and practice [ 142].
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