Exact(16)
Further development and refinement of methods to accurately and efficiently classify BRCA1 homozygous methylation status, and a suitably powered prospective clinical trial are required to validate our findings that homozygous BRCA1 methylation predicts PARPi sensitivity.
In a significant refinement of methods, we focus on providing public input to institutional practice and governance of biobanks using a tailored workbook structure to guide participants' discussion.
Running alongside this evolution has been the refinement of methods by which interfaces can be probed at scales approaching (or being at) the molecular.
Research Interests: Signal processing for hearing aids and auditory prostheses, computational modeling of the auditory periphery, and the use of intracochlear and cortical evoked potentials in the development and refinement of methods for coding sound for users of cochlear implants.
We suggest that the use of prior knowledge about CNVRs as provided by our maps, could yield the necessary refinement of methods.
Although increasing efforts have been put into the refinement of methods for the accurate and reliable detection of CNVs [9], [10], [11], [12], available methods suitable for high-density oligonucleotide SNP arrays still lack sufficient sensitivity and specificity [13].
Similar(44)
To address this ethical dimension, the "3Rs" concept is advocated: Refinement (of experimental methods to minimize harms and maximize benefits), Reduction (of the number of animals used), and Replacement (with alternative methods not using animals) [ 2].
We hope that refinement of these methods will enable us to produce a meaningful classification of documents in the Archimedes Project automatically.
Refinement of chromatographic methods is inseparable from refinement of detectors that accurately sense solutes in the presence of the mobile phase.
The field would benefit from a further refinement of research methods to identify processes of therapeutic change.
This is a tremendous task, as it requires the refinement of growth methods and nanoscale structural, optical, and electrical characterizations at the forefront of the present technologies.
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