We estimate that the parallel stochastic refinement is on average about 20 to 40 fold faster in comparison to the independent refinement of all candidate orientations.
The refinement of a set of candidate biomarkers can be achieved through many different pipelines.
We also propose a stochastic parallel refinement method that increases significantly the efficiency for the simultaneous refinement of a set of alignment candidates.
Further refinement of the candidate gene list will require knowledge of the role of these genes in defence response and correlation of transcript levels with resistance/susceptibility.
Notwithstanding the need for further refinement of candidate loci by genetic mapping, it is tempting to speculate on candidate genes in addition to BCL2L1 that may be involved in culture adaptation.
Iterative rounds of appraisal and refinement of candidate items resulted in 30 items with a daily recall period and 34 items with a 7-day recall period.
The feasibility of a candidate hinge loop is evaluated by using a refinement procedure described below, and its actual range will be identified as well.
LD maps have been used successfully in GWAS for refinement of candidate regions [ 24, 25].
Accurately defining the marker order on chromosomes is crucial for correct identification of quantitative trait loci (QTL), haplotype map construction and refinement of candidate gene searches.
The evaluation showed that the effort can lead to a considerable refinement of a given pre-clustering by the consequent exclusion of superfluous proteins from complex candidates.
