In the past decade, progress in hardware development, improvement in simulation methodologies and refinement of interaction potentials have rendered the possibility to model increasingly complex processes that were intractable previously (Karplus and Kuriyan, 2005).
During refinement, the interactions between symmetry-related toxin molecules were prevented by using 'igroup' statements in CNS refinement scripts.
The cell persists through phenotypic refinement, but without interaction with its environment, it would be unable to progress.
Following molecular dynamics refinement, side-chain interactions at the protein interface were identified that were predicted to contribute substantially to the free energy of binding.
The idea that people might optimize their behavior has had a long standing prominence as an applied and operational assumption, in that the classical central place models began with a "nearest" center assumption, though subsequent refinements in spatial interaction theory have allowed a much richer set of analyses.
What is particularly important as far as this paper is concerned is that the evolution of these pre-mRNAs into mRNAs was characterised by a progressive refinement of the interactions of the peptide-RNAs on the pre-mRNA templates and this refinement seems to have been made possible only when peptide-RNAs were transformed into amino acid-pre-tRNAs [ 4].
Elements with multiple interactions in the network will also enable greater refinement of predicted protein protein interaction networks when compared with other interactors.
Again, it is not the goal of this paper to provide a comprehensive list of potential visualizations or rule definition scenarios but rather underline the importance of a dedicated result refinement phase including human interaction as a cornerstone of ongoing policy management in IAM.
It is our view that, because Coulombic electrostatic terms focus exclusively on polar components of interaction networks, refinement with electrostatics is, at best, inadequate for improving the quality of low-resolution structure models.
The symmetry of the unit cell was determined by means of a force field constrained Rietveld refinement algorithm including nonbonding interactions (Lennard-Jones potentials) and chain continuation enforcement (penalty functions) in the force field.
