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Both tools allow for the capture of essential features of interactions between components in open architectures, therefore assisting in concept refinement, identification of actors, policy exploration and the feasibility assessment of new systems.
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Model-driven analyses on gene annotation refinement and identification of gene and enzyme essentiality analyses are helpful to understand the genome and discover promising novel drug targets.
This strategy will provide the highest chance of identifying genetic predictors of responsiveness to folate whilst simultaneously provide us with a resource, as knowledge of the genetics of these pathways increases, for future refinement and identification of other associations.
One of the most interesting findings of our phylogeographic refinement is the identification of a new clade E-V15155), which originated about 12 ka (95% CI: 8.6 16.4) in eastern Africa (posterior probability = 0.99) where it is currently mainly distributed.
Discussion between the field researcher and lead investigator was ongoing throughout the initial coding and this assisted in the refinement of nodes and identification of key themes.
Translating preclinical findings into new treatments for human osteoarthritis requires a critical appraisal and refinement of animal models, identification of those pathogenic mechanisms that are amenable to intervention, and pharmacological targeting of those mechanisms in the right people at the right time.
This MMDS refinement was validated through successful identification of small-molecule inhibitors of an MMDS-refined 3D model of a protease [15], [16].
Initial placement and refinement of this model allowed identification of twofold non-crystallographic symmetry, which was then used during early-stage map generation, model building, and refinement (final refinement was performed without non-crystallophic symmetry).
The large data set enabled refinement of minimal regions and identification of rare amplicons such as at 1p34 and 20q11.
The process of constructing this metabolic model led to suggested annotation refinements for 27 genes and identification of areas of metabolism requiring further study.
Now that the project is nearing launch, the refinement of resource estimates allows the identification of excess margin, which is being applied in novel ways to benefit the project both in development and in operations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com