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The second step (refinement) evaluates candidate segments with a probabilistic approach to assess the evidence for IBD.
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This uncertainty-driven DSM refinement was evaluated by comparing it to a second approach.
One-way and two-way interactive nesting errors with and without temporal refinement are evaluated.
A general summary of the steps includes: (1) Import and convert CCD micrographs; (2) Pick typical particles; (3) CTF determination; (4) Remove bad particles and build particle sets; (5) Make 2D reference-free class-averages; (6) Build an initial 3D model; (7) 3D high resolution refinement; (8) Evaluate the resolution of 3D map.
Furthermore, in order to guide the mesh refinement and evaluate the accuracy of numerical results, an error indicator based on the gradient distribution of the sound pressure is presented.
Progress in structure refinement was evaluated at each stage by the free R-factor and by inspecting stereochemical parameters calculated by the program PROCHECK [23].
The internal consistency of the scale after refinement was evaluated by calculating Cronbach's alpha coefficient [ 44].
In contrast to the deposited structural model, refinements were evaluated without using split-atom sites to model rotational disorder in the methyl group above 150 K.
Using these three approaches, the model can be refined and each iteration of the refinement can be evaluated by comparison with a previous version of the model.
We examine the benefits of the proposed method on the basis of some numerical examples in comparison to the same shape optimization method not involving adaptive mesh refinement where we evaluate the corresponding numerical costs, the gain in accuracy and the effects on the optimal shapes being obtained.
Although our questionnaire was aimed at assessing all types of physical activity, it lacked the level of refinement necessary to evaluate specific individual activities, such as walking.
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