Knowing which genes are involved and how they cause disease should allow the refinement of diagnosis and treatment.
Future studies should focus on the refinement of diagnosis utilising information on severity and duration of symptoms, alone, in combination and alongside dipstick testing.
There is increasing use of biochemical (and genetic) approaches for refinement of diagnosis and analysis of the relevant contribution of different disease processes to neurodegeneration of AD and other dementias [ 1, 3, 16, 18].
The active condition, as proposed in the present study might be a promising method to assess DOC and allow refinement of their diagnosis.
Remaining two or three different diagnostic hypothesis within the previous passive phase of diagnosis refinement, this new module can be fed with the vectors mapping each one of these diseases to elicit its associated set of clinical findings.
It is also suggested that the shared genetic liability between schizophrenia and bipolar disorder would make the genetic based refinement of the diagnosis of these diseases possible, which may also be tried for other diseases with overlapping symptoms [ 13].
This may or may not be correct, and is often based on their own or an acquaintance's previous experience of a problem, but it immediately directs subsequent refinement of the diagnosis.
