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Microstructural analysis of the SprayStirred (cold sprayed then friction stirred) specimens revealed significant particle refinement and improved particle distribution over the as-deposited coatings.
It is shown that the grain size and volume fraction of the β′ phase in the Cu Zn alloy should be kept small through proper heat treatment, and a die design with a wider groove can reduce stresses at the most severely loaded region of the workpiece, all of which allow higher numbers of pressings to attain better grain refinement and improved properties.
From these data, probes were designed using a home-made program (CADO4MI) allowing sequence refinement and improved probe specificity by combining the complementary information recovered from the UniGene and RefSeq databases.
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Competition works through diversity and selection; collaboration works through refinement and improving.
Overall, the transition from model A to model B demonstrates that HDX data can inform the manual refinement and improve homology models.
They may also allow for refinement and improve precision in risk estimation, and ultimately produce better tools for clinical risk assessment and decision-making regarding the use of chemopreventive agents [ 6].
If the Rfree of the refinement at resolution Y (calculated at resolution X) is lower than the Rfree of the refinement at resolution X (calculated at resolution X), then the additional higher resolution data between resolution X and Y is contributing meaningfully to the refinement and improving the overall structure.
It is hoped that the knowledge gained in unraveling the pathophysiology of coagulation and inflammation will result in further refinements and improved therapies for patients with severe systemic injuries and septic shock.
This international approach will provide a multifaceted view of AD, finding the commonalities and differences across ethnicities and cultures, allowing cross-pollination and promotion of ideas, refinement of techniques, and improved assistance that can directly and/or indirectly affect the care, and potentially the cure, of this devastating disease.
In steps 2 and 3 of the model refinement process, we assessed and improved the model by comparing its predictions to experimentally determined gene essentialities, derived from the ADP1 mutant collection [ 8] (see Figure 1).
Refinements in ligand design and improved reaction conditions for the racemic formation of hindered biaryls were key to the ultimate discovery of an asymmetric variant.
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