In later rounds of refinement, the model was refined with amplitude based twin refinement.
The structure obtained was further refined with the PHENIX refinement package phenix.refine [51] with iterative manual model building in COOT followed by density modification and refinement with phenix.refine.refine
The models were refined with a side-chain refinement and energy minimization process.
The model was refined with Refmac5 [75] using restrained maximum-likelihood refinement and TLS refinement [79].
The final isotropically refined model obtained with CNS was further refined with REFMAC_5 [70] using TLS displacement parameters.
With iterative refinements, the occluded pixels (black holes) will be successfully refined with the background.
To him (and to me) the elegant efficiency of prokaryotic machinery for gene expression seemed the more evolutionarily refined, with the loss of introns being but part of this refinement.
Data was scraped using ScraperWiki and refined with Google Refine; the resultant tables were merged using Google Fusion and finally visualised through Batchgeo.
Oils that have been refined with soda ash or ammonia generally require a light re-refining with caustic soda to improve colour.
Fisher's Titans run the vaunted "46" defense, which Ryan refined with the Bears and the Eagles.
