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The definition of an HBM index case was refined to require either of the following criteria: 1) a Z score greater than or equal to +3.2 at the L1 vertebra of the lumbar spine plus a Z score greater than or equal to +1.2 at the total hip or 2) a Z score greater than or equal to +3.2 at the total hip plus a Z score greater than or equal to +1.2 at the L1 vertebra of the lumbar spine.
The structure could be further refined to require that the neutral seat be renominated by a majority vote of the other four members every two years.
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The instrument is ready to be used by pharmacy students, health care practitioners and academics and will continue to be refined as required.
The list was refined by requiring a gene to also be significantly, differentially expressed (q < 0.15; one tailed t-test) between male and female tud progeny (sex-differential expression was required to be in the same direction for the wild type and tud progeny experiments).
The coding framework will be refined; if required, data will be recategorised from one theme to another, and some themes will be reconfigured.
Refined mesh is required to improve the simulation accuracy, which would in turn makes the calculation more time consuming.
Reverse Engineering software packages are not able to automatically and robustly detect the sub-regions of a tessellated model; it generally results in a first trial subdivision which subsequently has to be refined, requiring a large amount of human intervention and high computational effort.
Furthermore, the results demonstrated that grid convergence is not achieved with grid levels that have moderate mesh sizes and showed that highly refined grids are required to obtain solutions with an acceptable level of accuracy in design problems that involve simulations of complex flow fields.
Refined methods were required to include at least two distinct peptides for each G protein isoform, as well as three transitions for each peptide being monitored.
It is very interesting to note that the plate model having all these refined features requires unknowns only at the reference plane.
More information and more refined methods however, require more resources.
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