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We subsequently refined the structure of the substrate-binding model by means of energy minimization, indicating that slight movements of residues I167, N173 and F212 enable the enzyme to adapt to 3-quinuclidinone (Figure 4c).
We have also refined the structure of the full-length CC to 12.4 Å resolution.
Our analyses have refined the structure of the latter two clusters, revealing some hitherto undescribed loci, plus some novel divergent homeobox loci that are in, or close to, the Obox array.
Thirdly, in taking a recommended decision analytical approach, 15 we refined the structure of a previous model by allowing prosthesis failure to occur in the first year after the primary hip replacement or after revision surgery.
We refined the structure of METTL3 ZFD against the multiple types of restraints as well as knowledge-based restraints to enforce Zn2+-coordination geometry (Peters et al. 2010).
We refined the structure of lamprey ER with E2 and 15α-OH-E2 and human ERα with 15α-OH-E2 using Discover 3 in Insight II.
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grubii, we also identified novel exons and refined the structures of several annotated exons.
Furthermore, RNA-seq can detect genes expressed at low levels and refine the structure of transcripts (Wang et al. [2009] Wilhelmm and Landry [2009]).
The SAR analyses will guide us to further refine the structure of the thieno[3,2-d]pyrimidine derivatives to achieve optimum anticancer activity.
We begin with some observations on the structure of von Neumann regular right self-injective rings which will help us in refining the structure of endomorphism rings of ({mathcal {X}} -automorphism invariant and ({X}} -automorphismomorphinvariantandant modules.
The presence of pseudo-symmetry [16, 17] is sometimes a problem when trying to refine the structure of a material that undergoes a subtle phase transition – unit cell doubling for example can lead to highly collinear combinations of atom position parameters; the only data about the specific differences between the average and doubled cell are present in the weak superstructure reflections.
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