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We subsequently refined the structure of the substrate-binding model by means of energy minimization, indicating that slight movements of residues I167, N173 and F212 enable the enzyme to adapt to 3-quinuclidinone (Figure 4c).
We have also refined the structure of the full-length CC to 12.4 Å resolution.
Using correlated optical spectroscopy and X-ray diffraction data collection, we determined that the FAD is reduced by X-ray irradiation, and we refined the structure with FADH2.
Our analyses have refined the structure of the latter two clusters, revealing some hitherto undescribed loci, plus some novel divergent homeobox loci that are in, or close to, the Obox array.
Rietveld methods were unable to give accurate positions for the light ions in the presence of the heavy ions, so Thangadurai et al. refined the structure by minimizing the global instability index, G.
Thirdly, in taking a recommended decision analytical approach, 15 we refined the structure of a previous model by allowing prosthesis failure to occur in the first year after the primary hip replacement or after revision surgery.
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grubii, we also identified novel exons and refined the structures of several annotated exons.
The products are studied by XRD to refine the structure.
Furthermore, RNA-seq can detect genes expressed at low levels and refine the structure of transcripts (Wang et al. [2009] Wilhelmm and Landry [2009]).
The SAR analyses will guide us to further refine the structure of the thieno[3,2-d]pyrimidine derivatives to achieve optimum anticancer activity.
Consolidation and inter-docking of these frameworks or domains then stabilizes the overall conformation and refines the structure to activate the enzyme.
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