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The current work has further refined the application, incorporating mitomycin-C treatment to reduce any confounding contribution of proliferation and demonstrating how chemotaxis and chemokinesis can be assessed in the same experimental setup.
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Recent advance in cellular tissue-engineered skin constructs have refined the applications already commercially available, in particular, by the use of genetically modified cells to enhance their properties on the treatment of wounds and to ease the application of epidermis using sprayed keratinocytes.
"The way forward is refining the application of the criminal law".
He told BBC Radio: "It may be we need to be more clever than we already are in assembling evidence that can be used in a criminal court … The way forward is refining the application of the criminal law".
Our analysis refines the application of transaction cost economics to the understanding of the role of management accounting in different governance mechanisms.
After that, he spent two months on refining the application and worked with a designer to make it user-friendly.
In terms of methodological development, our research goes some way to developing and refining the application of theoretical perspectives of trust and intelligence in the context of hospital board governance.
We refined the design of the application and the accompanying dashboards as the epidemic evolved, largely due to the lack of standardized contact tracing protocols and metrics agreed upon by all partners.
The obtained solutions may be refined by the application of more sophisticated models.
ForSyDe is a transformational system design methodology, where an initial abstract system model is refined by the application of semantic-preserving and non-semantic preserving design transformations into a detailed model that can be mapped to an implementation.
The initial coding framework was revisited and refined through the application of the codes to all the textual data; for example, by identifying new sub-categories and collapsing together linked categories.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com