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Whereas early pain imaging studies mainly provided cartography of the areas activated by a painful stimulus, recent studies have used refined study designs that allow the respective roles of the different areas of the pain-matrix in the processing of pain to be disentangled.
In a further experimentally refined study, the same group (Wang et al., 2014) encapsulated 225Ac in multilayered polymersomes and varied the diameter of the inner and outer layers as well as the thickness of the membranes.
This visualisation enables refined study of chains of discrete effects with spatial and temporal overlap, and permits an informative comparison between the two age groups.
Strangely enough, "La Bête" is let down by its words, as Mr. Rylance's refined study in vulgarity triumphs in a far too-lopsided battle.
The Florentine sculptor Desiderio da Settignano's mid-15th century high-relief profile (from the Louvre) is an imaginative, extraordinarily refined study of the mature ruler.
Ms. Coolidge, playing the perpetually pregnant Edith Potter, provides the kind of refined study in vulgarity more commonly found in restoration comedies.
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Applying a finite-element submodelling approach, the microstructure was digitally reconstructed and refined studies carried out in regions where fatigue damage was observed.
Although this study cannot quantify the extent to which a given housing or neighborhood factor affects health status, it does identify avenues for more focused and refined studies.
Thus, the characterisation of the relationships between genetic aberration and clinical presentation is ongoing and will require further, more refined, studies with detailed investigations of this chromosome region and consistent phenotyping of affected individuals.
US conceived the study, helped refining study design, participated in statistical analysis and provided feed-back in successive manuscript drafts.
BB, SP, TS and FAO helped refine study methods and contributed to the collection and management of study data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com